Reply To: A Hello to Virology
“Electron micrographs of dengue HA antigens isolated in sucrose gradients (145,000 magnification); bar = 50 nm. (a) Rapidly sedimenting HA (RHA) contains complete virions. (b) Slowly sedimenting native HA (SHA) treated with Tween-80 and ether contains “ring” structures. (c) Slowly sedimenting HA derived from complete virions by Tween-80-ether treatment (derived SHA) contains aggregates of small doughnut particles each measuring 7 nm in diameter.”
Summary: a) Intact dengue virus. Everything else: Pieces of viral particles, etc.